Protein Details: Chloride channel protein CLC-a

Protein ID

ICDB_Pro_0710

Protein Name

Chloride channel protein CLC-a

Gene Name

CLC-A; CBSCLC5; At5g40890; MHK7.12

Organism

Arabidopsis thaliana (Mouse-ear cress)

Length

775 amino acids

AlphaFoldDB

AF-P92941-F1-model_v4.pdb

Function

Voltage-gated chloride channel that could play a role in the regulation of nitrate content.

Sequence

MDEDGNLQISNSNYNGEEEGEDPENNTLNQPLLKRHRTLSSTPLALVGAKVSHIESLDYEINENDLFKHDWRSRSKAQVFQYIFLKWTLACLVGLFTGLIATLINLAVENIAGYKLLAVGYYIAQDRFWTGLMVFTGANLGLTLVATVLVVYFAPTAAGPGIPEIKAYLNGIDTPNMFGFTTMMVKIVGSIGAVAAGLDLGKEGPLVHIGSCIASLLGQGGPDNHRIKWRWLRYFNNDRDRRDLITCGSASGVCAAFRSPVGGVLFALEEVATWWRSALLWRTFFSTAVVVVVLRAFIEICNSGKCGLFGSGGLIMFDVSHVEVRYHAADIIPVTLIGVFGGILGSLYNHLLHKVLRLYNLINQKGKIHKVLLSLGVSLFTSVCLFGLPFLAECKPCDPSIDEICPTNGRSGNFKQFNCPNGYYNDLSTLLLTTNDDAVRNIFSSNTPNEFGMVSLWIFFGLYCILGLITFGIATPSGLFLPIILMGSAYGRMLGTAMGSYTNIDQGLYAVLGAASLMAGSMRMTVSLCVIFLELTNNLLLLPITMFVLLIAKTVGDSFNLSIYEIILHLKGLPFLEANPEPWMRNLTVGELNDAKPPVVTLNGVEKVANIVDVLRNTTHNAFPVLDGADQNTGTELHGLILRAHLVKVLKKRWFLNEKRRTEEWEVREKFTPVELAEREDNFDDVAITSSEMQLYVDLHPLTNTTPYTVVQSMSVAKALVLFRSVGLRHLLVVPKIQASGMSPVIGILTRQDLRAYNILQAFPHLDKHKSGKAR

PDB Structures

7XA9 8IAB 8IAD

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Broadly expressed in the plant

DOI ID

10.1074/jbc.271.52.33632; 10.1046/j.1365-313x.2000.00680.x; 10.1093/dnares/5.2.131; 10.1111/tpj.13415; 10.1126/science.1088305; 10.1186/1471-2164-10-200; 10.1104/pp.109.138677; 10.1111/pce.12837

RefSeq

NP_198905.1 [P92941-1]